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• Time of issue:2021-02-05 15:19
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(Summary description)Recent research presented at the annual meeting of the European Society of Endocrinology suggests that intermittent fasting may have serious effects on a person's metabolism. This is the first study to show that intermittent fasting diets may actually damage the pancreas and affect insulin function in normal healthy people, which can lead to diabetes and serious health problems. Specifically, the new study, led by Ana Claudia Munhoz Bonassa, a researcher at the University of São Paulo in Brazil, suggests that intermittent fasting may impair normal pancreatic activity and insulin secretion, which in turn may increase the risk of type 2 diabetes. In their study, the researchers found that fasting for short periods of time increased oxidative stress and free radical production. Oxidative stress and excess free radicals accelerate the aging process and damage our DNA, increasing the risk of cancer, cardiovascular disease and neurodegenerative disorders. To find out if intermittent fasting does produce free radicals, Bonassa and her colleagues placed healthy adult rats on a diet for three months. During this time, the researchers measured and monitored the rodents' insulin levels and function, body weight and free radical levels. At the end of the dieting period, the rats lost weight as expected. However, the distribution of fat in their bodies changed in a surprising way. The amount of abdominal adipose tissue increased in the rodents. Recent studies have shown a strong relationship between abdominal fat and type 2 diabetes, and some studies have even suggested a molecular mechanism by which the former may lead to the latter. In addition, Bonassa and colleagues found signs of damage to insulin-secreting pancreatic cells, as well as higher levels of free radicals and insulin resistance. Commenting on the findings, the study's lead author said, "We should consider that overweight or obese individuals who choose an intermittent fasting diet may already have insulin resistance. Although such diets may lead to rapid weight loss early on, they may cause potentially serious damage to their health in the long term, such as the development of type 2 diabetes." In the future, the scientists plan to study in more detail the damaging effects of intermittent fasting on the normal function of the pancreas and insulin. This article is reprinted from other websites. We produce APIs and intermediates for the treatment of type 2 diabetes, please feel free to contact us if you need!