Company News_News_ Zhongshan Haihong Pharmaceutical Co., Ltd.

Will the expiration date of the medicine be shortened after opening?

The expiration date of the drug refers to the approved period of use of the drug, indicating that the drug under the specified storage conditions to ensure the quality of the period. After opening, the drug may undergo various changes due to contact with air and under the influence of temperature, humidity, light and other factors, which may easily affect the efficacy of the drug and may shorten its use period. Therefore, it is necessary to place the drugs in strict accordance with the specific storage conditions marked on the drug instructions. After opening, the duration of use of bottled drugs is about 2 months at room temperature of 25℃. When used again, it is not suitable for use if the following conditions occur: discoloration, moldy spots, obvious changes in smell or taste; loose tablets or pills, rupture of sugar-coated tablets, appearance of off-color patches or spots, autolysis, etc.; softening of capsules or serious adhesion on the surface, etc. Bagged medicine is mostly granules or powder, which is easy to expire, so it should be used up within 1 month after opening. Once there is moisture absorption, softening caking, dampness and other phenomena, should not be used. Liquid preparations, such as syrup, can be stored at room temperature of 25℃ for 1-3 months after opening, generally not more than 3 months in winter and not more than 1 month in summer. If there is acidity, gas, flocculent suspension, precipitate discoloration, crystallization and other deterioration phenomena, it can no longer be used. Ointment can be kept at room temperature for 2 months at most. If there are obvious particles, dissolution, water and other phenomena, it should not be used. There are many things that need to be paid attention to after the opening of drugs, for the efficacy of drugs and human health, or need to strictly follow the instructions for storage and use, and need to understand certain knowledge of drug storage, in order to better play their role.

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How should we store the medicines we always use at home?

First of all, medicines cannot all be put together. There are three reasons for this: one is because in the long-term storage of drugs, temperature, humidity and other environmental factors will have an impact on them, and complex physical and chemical changes occur. If topical and internal drugs are stored together, they will affect each other. Secondly, there is a risk of confusing the medication and causing harm to the human body. For example, the topical drug Furfuryl Glycolate, the appearance of which is very similar to the strawberry-flavored suspension, can easily cause misuse. Third, it is also unsafe to mix adult and children's medication. Because both may have the same name and similar appearance, but with different specifications, if adult medicines are mistakenly given to children, they may cause serious harm to them. Therefore, it is best to keep all medicines separately. Secondly, many people will keep medicines in the refrigerator, which actually depends on the situation, different drugs are stored under different conditions. The storage temperature of medicines include: room temperature (0℃-30℃), such as Azithromycin dry suspension; cool (0℃-20℃), such as Kratom Bay Combination. Some drugs also require sealing, avoiding light, drying, etc. For example, the solubility of drugs in syrup agents at too low a temperature may decrease, resulting in drug concentrations that do not match the label; creams are kept at too low a temperature, which may cause stratification of the matrix and affect its uniformity and efficacy. Therefore, the preservation of drugs or to comply with the requirements of the word "storage" on the outer packaging or instructions.

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What should I pay attention to after opening the medicine?

Nowadays, many families are equipped with commonly used drugs, and it is very common to store and reuse drugs after opening if they cannot be used up at once. However, it is necessary to understand that there are many matters that need to be noted after the opening of medicines. How to deal with the cotton, desiccant, etc. in the medicine after opening? Cotton or white paper are often seen in the bottles of medicine, which mainly play the role of filling to avoid damage to the medicine due to violent shaking and vibration during the transportation process. And the desiccant attached to the medicine is to absorb moisture and keep the dry environment in the medicine bottle, which is conducive to the stable preservation of the medicine. When the medicine is opened, there is generally no risk of violent shaking, so the cotton or white paper can be "retired". However, desiccant is not recommended to be discarded immediately, because its drying function is sustainable and can persist until the drug is used up. Therefore, when you take the medicine, you should pay attention to the sealing of the medicine bottle and don't open the cap for a long time, so as to avoid that the quantitative desiccant will over absorb the moisture in the atmosphere and become invalid. Of course, if it is clearly written in the instruction that the desiccant will cause harm to the medicine and there are words such as "discard", it is necessary to adjust the treatment immediately.

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Haihong science: knowledge of common clinical emergency drugs

I. Adrenaline [Alias] Adrenaline. [Pharmacology] It has agonistic effect on both α and β receptors, which strengthens myocardial contraction, accelerates heart rate, increases myocardial oxygen consumption, causes contraction of skin mucosa and small blood vessels of internal organs, but dilates coronary blood vessels and skeletal muscle vessels, in addition, it has the effect of relaxing bronchial and gastrointestinal smooth muscle. [Indications] Rescue treatment of cardiac arrest, anaphylaxis, bronchial asthma. [Commonly used formulation] Injection: 1ml (1mg). [Precautions] 1. Use with caution for hypertension, organic heart disease, coronary atherosclerosis, diabetes mellitus, hyperthyroidism, digitalis poisoning, trauma and hemorrhagic shock, etc. Cardiogenic asthma is contraindicated. 2, adverse reactions: headache, palpitations, increased blood pressure, convulsions, pallor, excessive sweating, tremor, urinary retention. 3, subcutaneous injection or intramuscular injection, to change the injection site to avoid tissue necrosis, injection must be back to draw no return blood before injection to avoid accidentally into the vein, closely observe the changes in blood pressure and pulse rate during injection to avoid causing a sudden rise in blood pressure and tachycardia. 4, with this drug can increase myocardial and systemic oxygen consumption, so it must be fully oxygenated, pay attention to the occurrence of acidosis. Noradrenaline [Alias] Noradrenaline. [Pharmacology] It mainly agonizes α receptors, and has a weak agonistic effect on β receptors, and has a strong vasoconstrictive effect to make the small arteries and small veins of the body contract, increase peripheral resistance, and increase blood pressure. [Indications] Various kinds of shock, hypotension, upper gastrointestinal bleeding, but hemorrhagic shock is prohibited. [Commonly used formulation] Injection: 1ml (2mg). [Precautions] 1, Contraindicated in patients with hypertension, arteriosclerosis, anuria. 2, adverse reactions: local tissue ischemic necrosis, urinary hypotension, urinary closure acute renal failure, headache, hypertension, reflex bradycardia. 3、When injecting, use a straight, large, elastic vein, strengthen observation, if the skin pale and painful, should immediately change the injection site, and phentolamine 5-10mg plus 0.9% saline solution for local infiltration injection, do not apply heat. 4, injection should start with a small dose, measure blood pressure at any time, adjust the speed of administration, so that blood pressure remains within the normal range. 5、This product is gradually discolored when exposed to light and should be stored away from light. 6、Inject with alkaline drugs such as aminophylline and sodium sulfamethoxazole. 7. Avoid prolonged use during resuscitation to avoid irreversible death due to poor capillary perfusion. Isoprenaline [Alias] Isoprenaline, asthma treatment. [Pharmacology] B agonist. Acts on β1 receptor, enhances myocardial contractility, accelerates heart rate, accelerates conduction, increases cardiac output and myocardial oxygen consumption, relaxes bronchial and intestinal smooth muscle. The coronary arteries are also diastolic to varying degrees, and the total peripheral resistance of blood vessels is reduced, promoting glycogen and lipolysis to enhance tissue oxygen consumption. [Indications] Cardiac arrest, atrioventricular block, bronchial asthma, cardiogenic and toxic shock. [Commonly used preparations] Injection: 2ml (1mg). Tablet: 10mg. aerosol: 0.25%, 5%. [Precautions] 1. Angina pectoris, myocardial infarction, hyperthyroidism, pheochromocytoma, etc. are contraindicated. 2, Adverse reactions: headache, palpitations, dizziness, dry throat, nausea, chest pain, shortness of breath. 3. Closely observe the changes of ECG, pulse and blood pressure, and adjust the concentration and dose according to the patient's condition. 4、If the heart rate is >110 beats/min, ECG is abnormal or the patient has chest pain, stop the drug immediately and report to the doctor in time. 5、Teach the patient to use the aerosol, saliva and sputum can be pink after use, rinse the mouth after use to avoid stimulating the mouth and throat. 6、Continuous use can produce tolerance, patients should be informed not to abuse, and the number of inhalation and inhalation volume should be limited. IV. Lobeline [Alias] Lobeline. [Pharmacology] Excite the carotid sinus and aortic body chemoreceptor reflex excitation respiratory center, on the plant nerve first excitation and then inhibition. [Indications] Asphyxia in newborns, poisoning by carbon monoxide, inhalation anesthetics and other central depressant drugs, respiratory failure caused by pneumonia, diphtheria and other infectious diseases. [Commonly used preparations] Injection: 1ml (3mg). [Precautions] 1. Adverse reactions: nausea, vomiting, choking and coughing, headache, palpitations, etc. Large doses may cause brady

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Study shows for the first time that intermittent fasting may increase the risk of type 2 diabetes

Recent research presented at the annual meeting of the European Society of Endocrinology suggests that intermittent fasting may have serious effects on a person's metabolism. This is the first study to show that intermittent fasting diets may actually damage the pancreas and affect insulin function in normal healthy people, which can lead to diabetes and serious health problems. Specifically, the new study, led by Ana Claudia Munhoz Bonassa, a researcher at the University of São Paulo in Brazil, suggests that intermittent fasting may impair normal pancreatic activity and insulin secretion, which in turn may increase the risk of type 2 diabetes. In their study, the researchers found that fasting for short periods of time increased oxidative stress and free radical production. Oxidative stress and excess free radicals accelerate the aging process and damage our DNA, increasing the risk of cancer, cardiovascular disease and neurodegenerative disorders. To find out if intermittent fasting does produce free radicals, Bonassa and her colleagues placed healthy adult rats on a diet for three months. During this time, the researchers measured and monitored the rodents' insulin levels and function, body weight and free radical levels. At the end of the dieting period, the rats lost weight as expected. However, the distribution of fat in their bodies changed in a surprising way. The amount of abdominal adipose tissue increased in the rodents. Recent studies have shown a strong relationship between abdominal fat and type 2 diabetes, and some studies have even suggested a molecular mechanism by which the former may lead to the latter. In addition, Bonassa and colleagues found signs of damage to insulin-secreting pancreatic cells, as well as higher levels of free radicals and insulin resistance. Commenting on the findings, the study's lead author said, "We should consider that overweight or obese individuals who choose an intermittent fasting diet may already have insulin resistance. Although such diets may lead to rapid weight loss early on, they may cause potentially serious damage to their health in the long term, such as the development of type 2 diabetes." In the future, the scientists plan to study in more detail the damaging effects of intermittent fasting on the normal function of the pancreas and insulin. This article is reprinted from other websites. We produce APIs and intermediates for the treatment of type 2 diabetes, please feel free to contact us if you need!

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